PRF (platelet-rich fibrin), like PRP (platelet-rich plasma), is a platelet concentrate of your own blood. Blood consists of about 55% plasma, 40% red blood cells, and 5% platelets, white blood cells, and stem cells. Platelets secrete fibrin, a substance that acts as a matrix for collagen. Blood platelets are full of growth factors and cytokines, key factors for inflammation and wound healing. Cytokines also promote bone healing and full development of soft body tissue.
When platelets bind to a fibrin scaffold, they activate and release growth factors.
We spin about two teaspoons of your blood to prepare PRF for use. Your blood must be free of anticoagulants or other artificial chemicals. Because PRF does not require the use of additives, it is 100% natural.
Spinning concentrates white blood cells, platelets, growth factors, and stem cells. These separate from the blood during spinning, forming a fibrin clot…the PRF…between the plasma and the red blood cells. Its platelet concentration is ten times higher than in PRP! A PRF clot makes a strong natural-fiber matrix that concentrates almost all the platelets. PRF releases growth factors and stem cells over time, and intensifies rapid and accelerated wound healing and regeneration.
Uses for PRF
PRF stimulates inactive hair follicles into an active growth phase. Because of this, restorative treatments like hair regeneration can use PRF. Its slow molecular chaining and its fibrin-based structure make it a better healing material than PRP. Other uses include facial rejuvenation and sculpting, lessening deep nasolabial folds, improving the appearance of volume-depleted midface, superficial wrinkles, and acne scars. PRF may be injected or applied using microneedling.
You can improve the following using PRF:
- Dark circles
- Acne scarring
- Wrinkles and fine lines
- Tear troughs and deep folds
- Hair restoration and brow thickness
- Brown spots (face, neck, and décolleté
- Volume loss and symmetry adjustment
Other information about PRF
PRF study , National Institutes of Health
Platelet-Rich Fibrin (PRF) Treatment Natural Filler