Advanced Lipid Testing provides information on risk factors beyond the standard lipid tests for LDL, HDL cholesterol, and triglycerides. Two of the most common risk factors measured in ALT include apolipoprotein B(ApoB) and LDL-particle number (LDL-P). The total number of ApoB indicates the total quantity of bad cholesterol. LDL can occur as large buoyant LDL particles or as small dense LDL particles with less cholesterol per particle. These small dense LDL particles are more atherogenic—tending to promote the formation of fatty plaques in the arteries—than large buoyant LDL particles, and more easily invade the walls of the arteries, increasing the risk of plaque formation.
Advanced lipid testing may also include Lipoprotein (a) or Lp (a) and ApoA1. These are all simple blood tests. Advanced Lipid Testing may be recommended at the initial visit and at regular intervals. Sometimes, after successful achievement of the LDL cholesterol and non-HDL cholesterol goals, it is recommended to check the effectiveness of the lipid-lowering therapy with a combination of healthy lifestyle and cholesterol lowering medication.